DISSEMINATED INTRAVASCULAR COAGULATION: AN UPDATE FOR THE CLINICIAN Page 1 DISSEMINATED INTRAVASCULAR COAGULATION: AN UPDATE FOR THE CLINICIAN
نویسنده
چکیده
Disseminated intravascular coagulation (DIC) is a syndrome characterized by the systemic activation of coagulation, leading to widespread microvascular thrombosis which compromises organ perfusion and can contribute to organ failure. The ongoing activation of coagulation may exhaust platelet and coagulation factors, resulting in a hypocoagulable state and bleeding, particularly in patients at risk for blood loss, such as surgical patients. DIC is a complex and dynamic process; thrombosis and bleeding can occur separately or concurrently, and the diverse clinical characteristics of this disorder make diagnosis and management challenging. DIC is associated with substantial mortality in humans and in animals. Mortality rates of 50-77% are reported in dogs, and 93% in cats.
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